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Mayo Clinic is a not-for-profit organization. (37). Chromhidrosis is quite rare with limited information about the percentage of people potentially affected. Learning the ABCs of melanoma could save your life. Pictures of 15 Uncommon Skin Conditions - WebMD Is Chromhidrosis Behind Your Blue Toilet Seat? | livestrong While it isnt life-threatening, chromhidrosis often causes emotional distress. Geelhoed-Duijvestijn PHLM. Both were penicillin resistant, motile, and produced haemolysis on blood agar. Treatment for eccrine chromhidrosis tends to involve reducing or eliminating contact with the dye, chemical, or heavy metal responsible for the discoloration. JAMA Dermatol 2013; 149: 13391340. If a person with chromhidrosis experiences any symptoms of emotional or psychological distress, they should let a healthcare provider know. Khanna A, Khanna M, Aggarwal A. Serratia marcescens a rare opportunistic nosocomial pathogen and measures to limit its spread in hospitalized patients. The ubiquitous bacteria have a predilection for starches and are rarely found in bacteriological skin cultures. Accessed June 28, 2022. These symptoms can include: There are a few possible causes of chromhidrosis, depending on the type. The infected skin is red with pus-filled blisters that. 4). Eccrine chromhidrosis may occur anywhere on the body, as eccrine glands are widely distributed, except in areas such as the lips. Harada K, Morohoshi T, Ikeda T, Shimada S. A patient with pseudochromhidrosis presenting with pink nails. Hyperhidrosis treatment usually helps. Hand-foot-and-mouth disease is a mild, contagious viral infection common in young children. Pediatr Dermatol 1984; 2: 3840. International Hyperhidrosis Societyhas been awarded as a Top-Rated Nonprofit since 2012! These colors are due to a pigment produced in the sweat glands called lipofuscin. Once the cause has been confirmed, they can help you determine the best course of action: ghosting the culprit, treating it (with antibiotics, for example) or replacing it with another option (say, a different medication) that doesn't trigger colored sweat. causes the sweat glands to secrete colored sweat. Rogolsky M. Genetic mapping of a locus which regulates the production of pigment associated with spores of Bacillus subtilis. [2] It is caused by the deposition of lipofuscin in the sweat glands. Acral green pigmentation (eccrine chromhidrosis). They are a result of evolutionary competition to overcome hosts, other microorganisms, and environmental challenges. Thami GP, Kanwar AJ. American Academy of Dermatology Association. Fig. Accepted Oct 14, 2019; E-published Oct 14, 2019, Corr: Christoffer Ingvaldsen, Department of Plastic and Reconstructive Surgery, Rikshospitalet, Oslo University Hospital, Postboks 4950 Nydalen, NO-0424 Oslo, Norway. Hand-foot-and-mouth disease - Symptoms and causes - Mayo Clinic Hyperhidrosis (hi-pur-hi-DROE-sis) is excessive sweating that's not always related to heat or exercise. Apocrine chromhidrosis over dorsum of foot: a case report. Some people may benefit from therapy, counseling, medication for anxiety or depression, or a combination of these approaches. Due to her reports of hypohidrosis, a sweat provocation test with following sweat pH measurements (Jenway pH meter, Model 3510, Cole-Parmer, Staffordshire, UK) were performed. Turnbull PCB. Lycopene, the bright red pigment found in tomatoes, is one of the carotenoids produced (95). Chromhidrosis, colored sweat. In the case of chromhidrosis caused by chemicals, treatment tends to involve reducing contact with dyes and heavy metals. Apocrine chromhidrosis. Chromhidrosis does not threaten your health. Children should stay home from school or child care for at least 48 hours after the last time they . Norovirus spreads very easily and quickly in different ways. Hyperhidrosis - Symptoms and causes - Mayo Clinic The reported colours are yellow (5), red (4345), pink (46, 47), blue (2, 37, 38), green (36, 48), brown (39, 40), and black (44, 49, 50), most commonly localized on the face, neck, and palms (2). Beer K, Oakley H. Axillary chromhidrosis: report of a case, review of the literature and treatment considerations. Chang YC, Anderson N, Soeprono F. Bilateral facial pigmentation. This is a pigment that is produced as a byproduct of the oxidization of lipids (fats) in some types of cells. They're the sweat glands responsible for controlling body temperature, keeping skin hydrated and protecting the skin barrier. Pseudochromhidrosis. A case of generalized red sweating. Eccrine chromhidrosis. Its impossible to prevent melasma. information and will only use or disclose that information as set forth in our notice of Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, Butt sweat: Why it happens and how to get rid of it, a general feeling of hopelessness, worthlessness, helplessness, guilt or pessimism, a persistent anxious, sad, or empty mood, a decrease in energy or increase in fatigue, a lack of interest in once enjoyable activities, trouble concentrating, making decisions, or remembering, stimuli such as anxiety, sexual arousal, or pain, certain medications, such as bisacodyl, a laxative, when it is coated in tartrazine, a yellow dye, applying a capsaicin cream once or twice a day, though this can cause a burning sensation. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Skin Diseases: Types of, Symptoms, Treatment & Prevention Mol Microbiol 2005; 56: 971989. With pseudochromhidrosis, sweat takes on an unusual color after secretion from the sweat gland as it comes in contact with dyes, chemicals, or chromogenic bacteria on the skin (bacteria that produce pigments.). Chromhidrosis - About the Disease - Genetic and Rare Diseases The goal of treatment for chromhidrosis is to reduce symptoms in order to also reduce any related psychosocial impacts or stigma. Based on the literature review, bacteriological tests should be the first diagnostic step when dealing with coloured sweat and/or atypical skin discolouration. Bromhidrosis: Causes, Treatment, and More - Healthline Fig. Banerjee D, Mondal A, Gupta M, Guha AK, Ray L. Optimization of fermentation conditions for green pigment production from Bacillus cereus M116 (MTCC 5521) and its pharmacological application. Hurley HJ, Witkowski J. Dye clearance and eccrine sweat secretion in human skin. It is well known that the bacteria can colonize moist skin surfaces and can cause a greenish discolouration of skin, nails, clothes, and surgical dressings (48, 62, 64, 65). Please tell us where you sweat so we can help you and others. In: Dermatology: An Illustrated Colour Text. Snider DE, Jr., Farer LS. Articles in English, German, French, Dutch, and Danish were included. Red pseudochromhidrosis of the neck. 3). Two different isolates were cultured; a greyish culture and a greyish culture with a blue tint (Fig. Lipofuscin is common in human cells, but for some reason people with chromhidrosis have higher concentrations of lipofuscin or lipofuscin that is in a higher-than-normal state of oxidation. Chromhidrosis is a rare condition characterized by the secretion of colored sweat. Skin scrapings for dermatophyte PCR identification were taken from the female and male patient. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Health Products for Men and Women from Mayo Clinic Store, Newsletter: Mayo Clinic Health Letter Digital Edition. Characterization and incidence of pigment production by human clinical group B streptococci. The potential triggers, causative microorganisms, diagnostic approaches, and suggested treatments for infectious pseudochromhidrosis are addressed. Chromhidrosis is a rare chronic condition that causes sweat to turn black, blue, green, yellow, or brown. Dermatol Monatschr 1972; 158: 18. Symptoms are usually worse during the first 2 to 3 days, and this is when you're most likely to spread the virus. Uzoma M, Singh G, Kohen L. Green palmoplantar vesicular eruption in a patient with hyperbilirubinemia. Microbiol Immunol 2017; 61: 490496. This process might involve your doctor testing skin scrapings, secretion smears and extraction samples from clothing. Acta Derm Venereol 2009; 89: 538539. triggered by topiramate (an antiepileptic drug) (38). Corynebacterium species brown/black IPCH (44, 49, 50): Corynebacterium is a genus of Gram-positive and (mostly) aerobic rods that is widely distributed in nature. Because apocrine glands don't start functioning until puberty (when hormonal stimulation begins), this form of chromhidrosis is typically more prominent when a person is younger, with symptoms becoming less severe as they age (as apocrine secretion tapers off). Lack of interest in activities you once enjoyed. Chromhidrosis (from Greek: chroma [colour] and hidros [sweat]) is a rare dermatological disorder characterized by coloured sweat (1). Cardiovascular health: Insomnia linked to greater risk of heart attack. Apocrine chromhidrosis results in only yellow, green, blue, black and brown sweat. This is a rare dermatological disorder named infectious pseudochromhidrosis. Epidermolysis bullosa, a connective tissue disorder that causes fragile skin that blisters and tears easily. The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity. He or she will likely want to take the necessary steps to rule out potentially more serious medical conditions before making a diagnosis of chromhidrosis. One study from Hiroshima reported large amounts of intracellular, purple pigment (copper coproporphyrin III) in a B. cereus strain (81, 89). Get inside intel, research results, event invites! pH measurements of sweat were considered normal (mean/minmax: 5.6/5.16.5). An accurate diagnosis is the first step to getting this rare form of psoriasis under control and getting relief. To our knowledge, no definition of this disorder has been proposed. If a person notices any coloration, they should consult a doctor. Oliveira A, Oliveira LC, Aburjaile F, Benevides L, Tiwari S, Jamal SB, et al. Indian J Dermatol 2017; 62: 675. Hyperhidrosis. Role of melanin pigment in expression of Vibrio cholerae virulence factors. that produced black pigment (with the proposed name C. nigricans) (97). IPCH case reports (Table I) did, however, have blue-coloured sweat (which could potentially be pigments from B. cereus). Bromhidrosis is foul-smelling body odor related to your sweat. Chromhidrosis causes the sweat glands to secrete colored sweat. The scope of this article was, therefore, to report another case of IPCH and to review the literature. If a person notices any coloration, they should consult a doctor. There are also several case reports where IPCH has been suspected despite negative cultures (5, 43, 44, 51, 66). https://www.sweathelp.org. Manual expression of the apocrine glands (where you carefully squeeze the glands to empty them, similar to how you'd pop a zit) can also offer relief, but the results only last up to a few days. While it can occur at any age, its most often noticeable after puberty. It may be associated with hyperhidrosis. Hines Dermatology Associates Inc., Attleboro, MA, Highly regarded dermatologist and dermatopathologist. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Sweating, excessive. https://www.uptodate.com/content/search. Clin Exp Dermatol 2004; 29: 548549. Wolters Kluwer; 2019. J Bacteriol 1981; 147: 900913. An on-site dermatopathology laboratory reduces the time spent waiting on a diagnosis. With this condition, your sweat is colorless, but when it interacts with something else on your skin bacteria, dye, chemicals from cleaning products, say a color change occurs. Clin Auton Res 2015; 25: 153159. The bleeding usually stops on its own, and it's not serious, although it can make . J Bacteriol 1953; 65: 509510. reviewed pigment production in Corynebacterium spp., and reported that carotenoid production is one of many important virulence factors (59). All rights reserved. Anyone who has chromhidrosis should speak with a healthcare provider if they start to experience symptoms of emotional distress, depression, or anxiety. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, International Hyperhidrosis Society (IHS), https://www.sweathelp.org/where-do-you-sweat/other-sweating/chromhidrosis.html, https://cdn.ymaws.com/www.aocd.org/resource/resmgr/jaocd/contents/volume30/30-05.pdf, https://adaa.org/understanding-anxiety/depression/symptoms, https://www.ncbi.nlm.nih.gov/books/NBK554395/. Saff DM, Owens R, Kahn TA. Apocrine glands develop in areas with many hair follicles, such as on the scalp, armpits and groin. Chromhidrosis (Colored Sweat) - International Hyperhidrosis Society Insight of genus corynebacterium: ascertaining the role of pathogenic and non-pathogenic species. (a) Blue discolouration on dorsal side of the hand primarily covering the joints. Drewnowska JM, Zambrzycka M, Kalska-Szostko B, Fiedoruk K, Swiecicka I. Melanin-like pigment synthesis by soil bacillus weihenstephanensis isolates from northeastern Poland. Yoshida R, Kobayashi S, Amagai M, Tanaka M. Brown palm pseudochromhidrosis. Those substances might include water-soluble dyes, heavy metals (like copper), excess food coloring or flavoring, as well as certain medications (rifampin, an antibiotic; quinines, an antimalarial; and levodopa, a dopamine precursor used to manage Parkinson's). Galveston, TX: University of Texas Medical Branch at Galveston, Dept of Microbiology & Immunology, 1996. It can occur weeks or years after infection with the TB bacteria. Cilliers J, de Beer C. The case of the red lingerie chromhidrosis revisited. Here's what experts have managed to suss out about this puzzling skin condition so far: Apocrine, eccrine and pseudochromhidrosis each show up a bit differently and have their own underlying causes, Daniel Friedmann, MD, board-certified dermatologist at Westlake Dermatology in Austin, Texas, tells LIVESTRONG.com. 2. Urine, stool, saliva, and tears were normal coloured. Chromhidrosis. Blue Toilet Seat? Why Your Toilet Seat Is Turning Blue To prevent overheating, the body promotes heat loss through evaporation. The end result is usually nothing more than sticky skin and the occasional pit-stained tee but for a small percentage of people, sweating can also leave behind a blue toilet seat. You may prevent contagious skin diseases or reduce their symptoms if you: Avoid sharing utensils, personal items or cosmetics. Chromhidrosis | DermNet The primary treatments for apocrine chromhidrosis are topical agents antiperspirant (such as Drysol), to temporarily plug the pores causing you trouble, and capsaicin cream, to deplete nerve cells of Substance P, "an important chemical that controls aprocrine gland secretion," Dr. Friedmann says. The pigments described comprise a heterogeneous group of carotenoids (terpenoid pigments) (6772), melanins (7377), alkaloids (78, 79), porphyrins (80, 81), siderophores (65), and flavins (82). Although you typically feel better after a day or two, you're contagious for a few days after you recover. There are three types of chromhidrosis: apocrine, eccrine, and pseudochromhidrosis. Norovirus infection - Symptoms and causes - Mayo Clinic Moayedi A, Nowroozi J, Sepahy AA. Such psychological effects are likely very familiar to our hyperhidrosis readers and we welcome chromhidrosis sufferers to our community. What About Chromhidrosis During Pregnancy? Please select your country where you live. Chromhidrosis can subdivide into three categories: Apocrine chromhidrosis, eccrine chromhidrosis, and pseudochromhidrosis (pseudo-eccrine chromhidrosis). As sweat production on the hands and feet are similarly controlled, a comparable worsening of hypohidrosis might have been the case at both sites (3). Arch Dermatol 2005; 141: 795796. This tentative diagnosis has been strengthened by complete remission after antibacterial treatment, combining systemic and topical erythromycin in all cases. There are documented differences in the pH and hydration between paediatric and adult stratum corneum (102). Best food forward: Are algae the future of sustainable nutrition? (blue colour), Corynebacterium spp. reported blue skin discolouration due to Bacillus spp. Hyperhidrosis (hi-pur-hi-DROE-sis) is excessive sweating that's not always related to heat or exercise. Lett Appl Microbiol 2014; 58: 2530. Triwongwaranat D, Kasemsarn P, Boonchai W. Green pigmentation on the palms and soles. https://www.aad.org/public/diseases/a-z/hyperhidrosis-overview. Chromhidrosis is a disorder of the sweat glands that manifests with colored sweat on the face, in the underarms, or on the areola of the breasts (the darker circle of skin around the nipples). J Drugs Dermatol 2004; 3: 184186. The patient also reported staining of her clothes, towels, furniture, and shower. A novel red pigment from marine Arthrobacter sp. Avalos J, Carmen Limon M. Biological roles of fungal carotenoids. Sweating causes emotional distress or social withdrawal, You suddenly begin to sweat more than usual, You experience night sweats for no apparent reason. [A woman with blue sweat]. Red and black pseudochromhidrosis. Eccrine sweat glands are involved in hyperhidrosis, though apocrine glands may play a role as well. At the time of presentation, the patient was approximately 7 months pregnant with her first child. You can use pain relievers to feel better. In some cases, ingesting of certain substances causes discoloration of sweat. face, axillae, anogenital area, and breast areolae) that excrete small amounts of oily sweat (1, 3). Pink eye is commonly caused by viruses or bacteria. Certain activities such as hot showers and friction against the skin increase the likelihood of discolored sweat in people with chromhidrosis. Chromhidrosis is a serious skin disease that can significantly affect your quality of life. List of rare skin diseases: Pictures, symptoms, and treatments Sweat may be yellow, green, blue, brown, or black. The genus, however, which currently has more than 110 validated species, constitutes a very heterogeneous group (59). affecting the skin, including rare conditions such as chromhidrosis. It occurs most often in babies and small children. To date, none of the previous studies have specifically reported a blue pigmentation as a result of colonization with B. cereus. Eccrine chromhidrosis can affect the skin over any body area but is often worst on the palms and soles where eccrine sweat glands are most concentrated. Search terms included chromhidrosis, pseudochromhidrosis, coloured sweat, lipofuscin, bacterial pigment, fungal pigment, and promethazine sweat. Leonard RB, Nowowiejski DJ, Warren JJ, Finn DJ, Coyle MB. You may sweat so much that it soaks through your clothes or drips off your hands. However, this was less than was subjectively expected. Hill S, Duffill M, Lamont D, Rademaker M, Yung A. Pseudochromhidrosis: blue discolouration of the head and neck. Make a donation. reported a novel Corynebacterium spp. Moreover, pigment production seems to be a decisive factor determining survival, pathogenicity, and virulence among microorganisms. Marks JG, Jr. Pseudomonas aeruginosa blue-green IPCH (36, 48, 62): P. aeruginosa is a Gram-negative, aerobic coccobacillus, which is widespread in nature (63). from an intrauterine device or drinking water) and ammonium (9). She had started daily 25 mg promethazine due to pruritus 6 months earlier. If you're dealing with discolored sweat, schedule a visit with a dermatologist to get answers, rule out more serious conditions, and learn about treatment options. 2003-2023 International Hyperhidrosis Society. Afra S, Makhdoumi A, Matin MM, Feizy J. Ned Tijdschr Geneeskd 2005; 149: 583 (in Dutch). J Dermatol 2018; 45: 9194. If these don't help, you may need to try different medications and therapies. You may also get a fever. Chromhidrosis: Background, Pathophysiology, Etiology - Medscape Iranian J Basic Med Sci 2017; 20: 13311338. Dermatol Online J 2014; 21. pii: 13030/qt73k8k695. These glands are in the underarm and genital regions, as well as the scalp, torso, eyelid, outer ear canal and nipple areas. Pseudochromhidrosis is a condition where colourless, eccrine sweat becomes coloured by exogenous factors on the skin surface, such as chromogenic microorganisms (1, 2, 15, 3638) and chemical agents (3942). Bacillus. Red eccrine chromhidrosis with review of literature. Chromhidrosis is a disorder of the sweat glandsthat manifests with colored sweat on the face, in the underarms, or on the areola of the breasts (the darker circle of skin around the nipples). J Bacteriol 2010; 192: 30683077. Heavy sweating can disrupt your day and cause social anxiety and embarrassment. As stated in the methods section, hands and feet were the first regions to show blue-coloured sweat. Bromhidrosis, also known as osmidrosis or ozochrotia, is an unpleasant or offensive body odour due to any cause including poor hygiene, infections, diet or medications, or inherited metabolic disorders. Treatment of apocrine chromhidrosis with topical capsaicin. Eccrine chromhidrosis | DermNet Symptoms include sores in the mouth and a rash on the hands and feet. More than anything, patients with chromhidrosis report emotional distress in relation to their condition. What the Smell of Your Pimples Can Tell You About Your Skin Health, This Is Why Your Armpits Smell Even With Deodorant. Eccrine chromhidrosis is the production of coloured sweat from the eccrine sweat glands. J Am Acad Dermatol 2012; 67: e7475. J Clin Microbiol 1994; 32: 164169. We report here a case of blue infectious pseudochromhidrosis caused by pigment-producing Bacillus cereus and the results of a literature review. The pH of the skin surface and its impact on the barrier function. information is beneficial, we may combine your email and website usage information with Briggs JK. Apocrine chromhidrosis | DermNet Gaffney DC, Cooper HL. Singal A, Thami GP. Dr. Hines has extensive experience in both common and rare conditions. If cultures are negative, and antibiotic treatment does not lead to remission of symptoms, an in-depth medical history and broad diagnostic approach are of importance in determining an alternative cause for chromhidrosis. Taylor MJ, Lawton WD, Goldberg ID. Localized chromidrosis: a survey. Promethazine influences these sweat regulatory centres in a way that is not fully understood (101). It's common and affects people of all ages, races, and genders. Pseudochromhidrosis occurs when sweat interacts with certain substances, resulting in colored sweat. Treatments may involve: However, authors of a review point out that current treatment options are limited and may not be very effective They emphasize the need for more research. Cawley EP, Hsu YT, Sturgill BC, Harman LE, Jr. Lipofuscin (wear and tear pigment) in human sweat glands. J Dermatol 2006; 33: 230231. MNT is the registered trade mark of Healthline Media. Adv Biochem Eng Biotechnol 2015; 148: 449467. For patients with pseudochromhidrosis, antimicrobial medications may help balance bacteria to reduce colored sweat. Therapy with Botox injections is effective at reducing sweat. All tests were normal, apart from a slightly increased alkaline phosphatase (ALP) of 122 U/l (reference range 35105 U/l). If you are a Mayo Clinic patient, this could However, patients with the condition report stress and embarrassment, as well as anxiety and depression related to their symptoms. Dermoscopy of the discoloured areas revealed diffuse superficial pigmentation and an unmodified skin pattern (as postulated by Pistone et al. Panagoulias GS, Basagiannis CS, Tentolouris N, Stavropoulou E, Karnesis L. Colored sweat caused by pseudochromhidrosis. Infect Immun 2007; 75: 40624070. In other circumstances, health issues such as infection and liver problems may cause sweat to change color. Am J Dermatopathol 2014; 36: 853855. Chromhidrosis: Definition, causes, and treatment - Medical News Today Learn more here. 2). health information, we will treat all of that information as protected health The color and the vividness of the shade can vary from person to person. Indian J Dermatol 2016; 61: 454457. Rodriguez-Martin M, Rodriguez MS, Cabrera AN. Skin Pharmacol Physiol 2006; 19: 296302. Two out of 5 swabs from the male patient (pectoral region and foot) yielded the same bacteria. Tracking your daily activities for two to three weeks such as what you've eaten and any chemicals you've come into contact with leading up to your doctor's appointment can be helpful in determining your triggers and what the potential culprits might be. Autofluorescence of clothing as an adjunct in the diagnosis of apocrine chromhidrosis. Weismann K, Poulsen AG, Moller AF, Kobayashi T. A man with a reddish stained wash cloth. (9094). J Bacteriol 1968; 95: 24262427. There is no medical cause for this type of hyperhidrosis. Because it develops in the skin folds, inverse psoriasis can cause significant discomfort and distress. The authors have no conflicts of interest to declare. A single copy of these materials may be reprinted for noncommercial personal use only. Skin examination with a Wood lamp revealed fluorescence on hands, feet, and hair (Fig. Corynebacterium spp. Chromhidrosis - UpToDate Epilepsia 2001; 42: 13631365. Chromhidrosis is a harmless skin condition, but because colored sweat can be a symptom of something more serious, it's important to check in with your doctor or dermatologist for an official diagnosis. Leonard et al. Eccrine sweat glands occur over most of the body and open directly onto the skin's surface. Regulation of the biosynthesis of coproporphyrin III and its copper complex by oxygen and heavy metal ions. Chromhidrosis is a rare condition with a characteristic presentation of the secretion of colored sweat and was first reported by Yonge in 1709. Indian J Dermatol Venereol Leprol 2012; 78: 756758. All rights reserved. Clinicals pearls in dermatology 2017. However, when it does develop, there are ways to improve its appearance, and there are some treatments that are safe during pregnancy. Three different conditions can result in chromhidrosis (2): Apocrine chromhidrosis is an intrinsic condition limited to areas with apocrine glands (e.g. Combined use of ranitidine (H2-recepter antagonist) and lansoprazole (proton pump inhibitor) may trigger Bacillus colonization, as reported by Hill et al. PCRs for dermatophytes were negative. (As always, talk to your healthcare providerabout your individual situation to receive an accurate diagnosis before beginning any new treatment.). IPCH following administration of an antihistamine. Dermatology 1999; 199: 149152. Int J Dermatol 2010; 49: 562564.