A vascular etiology, related to either decreased fetal perfusion or thrombosis of the sampling site with subsequent embolization, is suggested.
In 1991 we reported a cluster of babies with limb abnormalities and suggested that chorionic villus sampling (CVS) was aetiologically associated with these defects.

By continuing you agree to the A vascular etiology, related to either decreased fetal perfusion or thrombosis of the sampling site with subsequent embolization, is suggested.T1 - Limb anomalies associated with chorionic villus samplingN2 - Data on outcome of pregnancy were obtained in 436 (94%) of 463 patients undergoing chorionic villus sampling (CVS) at Humana Hospital-Michael Reese between January 1, 1989 and November 30, 1990. The procedures were performed at 9.5, 9.5, 10.5, and 11 weeks' gestation. The limb malformations in the four affected infants were all very similar and were comparable to those described by others in association with CVS. Exactly what is chorionic villus sampling? Chorionic villus sampling (CVS) and amniocentesis are prenatal diagnostic procedures that are performed to detect fetal abnormalities. Three of the cases of limb malformations followed transcervical CVS; one followed a transabdominal procedure.

By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of UseMalformations attributed to the process of vascular disruption, Constriction Rings and Congenital Amputations of the Fingers and Toes in a Mild Case of Amniotic Band Syndrome, Congenital limb deficiencies in Alberta—a review of 33 years (1980–2012) from the Alberta Congenital Anomalies Surveillance System (ACASS), Birth Defects Research Part A: Clinical and Molecular Teratology, Fetal oromandibular limb hypogenesis syndrome following uterine curettage in early pregnancy, Birth Defects Research Part A: Clinical and Molecular Teratology, Anatomic and etiological classification of congenital limb deficiencies, Examining the evidence for vascular pathogenesis of selected birth defects, Directed Medical‐Genetics Family History Questions: Separating the Trees from the Forest, The Practical Guide to the Genetic Family History, Big risks in small groups: The difference between epidemiology and counselling, Birth Defects Research Part A: Clinical and Molecular Teratology, Chorionic villus sampling significantly affects fetal cardiovascular function, The Journal of Maternal-Fetal & Neonatal Medicine, Clinical geneticists in birth defects surveillance and epidemiology research programs: Past, present and future roles, Birth Defects Research Part A: Clinical and Molecular Teratology, Diagnostic Approach to Prenatally Diagnosed Limb Abnormalities, Diagnostica prenatale dei difetti congeniti: tecniche invasive e non invasive, Birth Defects Research Part C: Embryo Today: Reviews, Smith's Recognizable Patterns of Human Deformation, Smith's Recognizable Patterns of Human Deformation, Birth Defects Research Part A: Clinical and Molecular Teratology,
A recent report of the frequency of defects in any or all fingers in an unexposed control population enabled us to assess whether CVS is associated with an increased frequency of defects involving one or two fingers, as well as terminal transverse limb defects.The frequency of limb‐reduction defects affecting one or more fingers or toes, including those with constriction rings and tissue loss, in published studies of 20,236 children who had been exposed to CVS was compared with the frequency in 161,252 newborn infants who had not been exposed to CVS. These observations, in conjunction with others in the literature, suggest that there is an increased risk of limb anomalies associated with CVS. The absence of the distal portion of the third finger, with tapering and stiff joints, appears to be a distinctive effect of exposure to CVS. An adequate sample was obtained with a single attempt in each case. Chorionic villus sampling (CVS), sometimes called "chorionic villous sampling" (as "villous" is the adjectival form of the word "villus"), is a form of prenatal diagnosis to determine chromosomal or genetic disorders in the fetus.It entails sampling of the chorionic villus (placental tissue) and testing it for chromosomal abnormalities, usually with FISH or PCR. Data on outcome of pregnancy were obtained in 436 (94%) of 463 patients undergoing chorionic villus sampling (CVS) at Humana Hospital-Michael Reese between January 1, 1989 and November 30, 1990.

title = "Limb anomalies associated with chorionic villus sampling", abstract = "Data on outcome of pregnancy were obtained in 436 (94%) of 463 patients undergoing chorionic villus sampling (CVS) at Humana Hospital-Michael Reese between January 1, 1989 and November 30, 1990. An adequate sample was obtained with a single attempt in each case.

Three of the cases of limb malformations followed transcervical CVS; one followed a transabdominal procedure.